Assyrian and Akkadian traders

Assyrian and Akkadian traders spread the use of writing in the form of the Mesopotamian cuneiform script to Asia Minor and The Levant (modern Syria and Lebanon). However, towards the end of the reign of Sargon the Great, the Assyrian faction rebelled against him; "the tribes of Assyria of the upper country—in their turn attacked, but they submitted to his arms, and Sargon settled their habitations, and he smote them grievously".

The Akkadian Empire

The Akkadian Empire was destroyed by economic decline and internal civil war, followed by attacks from barbarian Gutian people in 2154 BC. The rulers of Assyria during the period between c. 2154 BC and 2112 BC once again became fully independent, as the Gutians are only known to have administered southern Mesopotamia. However, the king list is the only information from Assyria for this period.

Most of Assyria briefly became part of the Neo-Sumerian Empire

Most of Assyria briefly became part of the Neo-Sumerian Empire (or 3rd dynasty of Ur) founded in c. 2112 BC. Sumerian domination extended as far as the city of Ashur but appears not to have reached Nineveh and the far north of Assyria. One local ruler (shakkanakku) named Zāriqum (who does not appear on any Assyrian king list) is listed as paying tribute to Amar-Sin of Ur. Ashur's rulers appear to have remained largely under Sumerian domination until the mid-21st century BC (c. 2050 BC); the king list names Assyrian rulers for this period and several are known from other references to having also borne the title of shakkanakka or vassal governors for the neo-Sumerians.